If the patient seems to respond great to naproxen/NSAID and cortisone, what would be the reasoning for starting methotrexate or another second-line agent? Would part of it be in hopes of coming off the NSAID?
In our treatment of JIA, we often initially start with NSAID (e.g. naproxen) and may use corticosteroid joint injections for a few large joints. If this allows patients to achieve remission, then typically a disease modifying anti-rheumatic drug (DMARD) such as methotrexate is not required. However, if there is any residual disease activity after [...]