0:00 - Introduction by Dr. Lori Tucker 3:00 - Dr. Lori Tucker introduces Sheila Grant (Parent Speaker) and Dr. Polly Ferguson 5:55 - CRMO Presentation by Dr. Polly Ferguson: What we know about the cause of CRMO 7:00 - Basics of Immunology 8:00 - Immune Activation and Inflammation 9:50 - Immune System Cells 10:30 [...]
There are increasing efforts to collect information about children with CRMO into long-term research registries, to help learn more about this disease, treatments and outcomes. Some pediatric rheumatology centers have their own research registries, and some centers are collaborating together to collect this information. Canadian pediatric rheumatologists have formed a CRMO research group [...]
Many auto-inflammatory diseases can be triggered to flare when a person gets a virus. However, it is not known whether CRMO is usually triggered in this way, and there is no evidence to suggest common virus infections ‘cause’ the development of CRMO.
There is no evidence that particular climate or temperature changes are linked to the development of CRMO.
Talk to your pediatric rheumatology team- often the nurse or OT will have great tips for helping with pain. Talk to your pediatric rheumatology doctor to be sure your child’s treatment is maximized. Using Tylenol or Naproxen can be helpful if your child is not currently taking these; in some cases, a short course [...]
There are no consensus guidelines regarding the benefit of routine follow up MRI testing in CRMO, and there is a lot of discussion among “CRMO” experts about this issue. Many physicians treat based on symptoms and inflammatory signs; other physicians are focused on treating radiograph (x-ray or MRI) lesions. Since many CRMO lesions [...]
As outlined in Dr. Ferguson’s talk, there is no single gene that causes CRMO. Clinically available genetic testing will not help with making a diagnosis, nor will it help in selecting treatment. Treatment for CRMO is based on symptoms, inflammatory markers, and in some circumstances x-ray/MRI findings.
Many pediatric rheumatologists will consider more active treatment in children who have CRMO involving the spine. This may include the options listed above. Whether to treat spine lesions that are not causing symptoms, but identified on MRI, is controversial at the present time.
In Dr. Ferguson’s talk (see the video!), she describes the treatment options often used for children with CRMO. When Naproxen or other non-steroidal anti-inflammatory medications do not work, treatments may include bisphosphonates (bone medication), corticosteroids (to help with short term flares), methotrexate, or biologic medications. Discussing these options with your pediatric rheumatologist will help [...]
For many patients with CRMO, there is long term healing of the CRMO lesions. The bone may be left with an area of what is called ‘sclerosis’, which is like a scar, but this doesn’t mean the bone is weak; it is like healing after a fracture. It is less frequent that CRMO lesions [...]
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