Many children with JIA will take Naproxen and methotrexate together. Naproxen is a
medication with pain relieving properties, and has some anti-inflammatory effect as well when
taken regularly. Methotrexate is not a pain relieving medication, but works to control
inflammation in a very different way from Naproxen. Many children have good disease control
with this combination. Although sometimes parents are told by a pharmacist that one should
not take these medications together, in children and teens there is ample evidence that this
combination is safe as well as effective.