In Dr. Ferguson’s talk (see the video!), she describes the treatment options often used for children with CRMO.  When Naproxen or other non-steroidal anti-inflammatory medications do not work, treatments may include bisphosphonates (bone medication), corticosteroids (to help with short term flares),  methotrexate, or biologic medications.  Discussing these options with your pediatric rheumatologist will help select the best treatment for you or your child.