0:00 Opening remarks Jennifer Wilson, Methotrexate Webinar
2:03 Introduction about Cassie +Friends organization
2:48 Thank you to the sponsors: Nicola wealth, Abbvie, Amgen, Roche, Sobi
3:13 Information how to watch past sessions
5:10 Information about support network for JIA kids’ parents
5:50 Introduction of the speakers: Amy Mazzone (parent guest speaker), Abby Mazzone (patient guest speaker), Dr. Jaime Guzman (Pediatric Rheumatologist BC Children’s Hospital)
8:20 Opening points from Abby and Amy
9:40 Abby’s diagnosis and story
11:10 Abby began taking Methotrexate
17:25 Abby started the Methotrexate as injections
23:00 Tips from Abby to tolerate the injections
27:00 Pros and cons of taking Methotrexate shared by Abby
32:05 Importance of the blood work while being on Methotrexate
35:00 Introduction of Dr. Guzman
36:15 Opening points from Dr. Guzman
37:20 Conditions which Methotrexate is used for
37:50 A common story in the clinic
38:52 The basics of JIA
41:20 How Immune system works
42:55 Pros and Cons of JIA treatments
45:34 Pros and cons of no treatment
47:20 Treatment balance
49:17 Methotrexate History
52:05 Methotrexate is kind of chemotherapy
53:15 Dr. Guzman’s perspective on taking Methotrexate
55:38 Methotrexate Pros
57:50 Methotrexate Cons
59:12 How large Methotrexate risks are
1:00:30 Methotrexate intolerance
1:02:25 OPT-JIA Trial- Study to test ondansetron to prevent Methotrexate intolerance
1:04:47 UCAN Ride4kids to raise awareness about personalized medicine for pediatric arthritis
1:06:52 Opening points of Q&A session
1:06:55 Question to Dr. Guzman: Why Methotrexate is used prior to biologics, why just not start with biologics
1:10:24 Question to Abby: What do you like to have for breakfast the morning after you take Methotrexate
1:11:05 Question to Abby: Do you have many side effects the morning after you take Methotrexate and how long they last?
1:12:12 Question to Dr. Guzman: Are itchy feet and hot/cold sweats known as side effects of Methotrexate?
1:14:14 Questions related to reducing anticipatory nausea or how to deal with anxiety will be addressed by email and also a link to the past session related to behavioral depression will be shared.
1:14:43 Question to Abby and Dr. Guzman How common is dizziness with Methotrexate
1:15:30 Question to Dr. Guzman: Which administration is more effective: oral or subcutaneous?
1:17:25 Question to Abby and to Dr. Guzman: Have you heard about potentially doing injection in the stomach instead of arm?
1:19:24 Question to Dr. Guzman: When you increase the dosage of Methotrexate should you expect the side effects to be worse?
1:20:56 Question to Dr. Guzman: Can a child be on Methotrexate too long?
1:22:18 Question to Dr. Guzman: How Methotrexate support one another and how they work together?
1:23:50 Question to Abby: How do you feel with the addition of Humira?
1:25:30 Question to Amy: What is your advice on talking with a rheumatologist or a nurse when you’re feeling unsure, or questioning whether Methotrexate works or it’s been too long
1:27:25 Closing remarks by Jennifer Wilson
1:29:00 Gratitude to all speakers
1:29:07 Information about a survey and next scheduled sessions
1:30:45 Information how to support and donate to Cassie+friends
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