0:00 Opening remarks Jennifer Wilson, Methotrexate Webinar

2:03 Introduction about Cassie +Friends organization

2:48 Thank you to the sponsors: Nicola wealth, Abbvie, Amgen, Roche, Sobi

3:13 Information how to watch past sessions

5:10 Information about support network for JIA kids’ parents

5:50 Introduction of the speakers: Amy Mazzone (parent guest speaker), Abby Mazzone (patient guest speaker), Dr. Jaime Guzman (Pediatric Rheumatologist BC Children’s Hospital)

8:20 Opening points from Abby and Amy

9:40 Abby’s diagnosis and story

11:10 Abby began taking Methotrexate

17:25 Abby started the Methotrexate as injections

23:00 Tips from Abby to tolerate the injections

27:00 Pros and cons of taking Methotrexate shared by Abby

32:05 Importance of the blood work while being on Methotrexate

35:00 Introduction of Dr. Guzman

36:15 Opening points from Dr. Guzman

37:20 Conditions which Methotrexate is used for

37:50 A common story in the clinic

38:52 The basics of JIA

41:20 How Immune system works

42:55 Pros and Cons of JIA treatments

45:34 Pros and cons of no treatment

47:20 Treatment balance

49:17 Methotrexate History

52:05 Methotrexate is kind of chemotherapy

53:15 Dr. Guzman’s perspective on taking Methotrexate

55:38 Methotrexate Pros

57:50 Methotrexate Cons

59:12 How large Methotrexate risks are

1:00:30 Methotrexate intolerance

1:02:25 OPT-JIA Trial- Study to test ondansetron to prevent Methotrexate intolerance

1:04:47 UCAN Ride4kids to raise awareness about personalized medicine for pediatric arthritis

1:06:52 Opening points of Q&A session 

1:06:55 Question to Dr. Guzman: Why Methotrexate is used prior to biologics, why just not start with biologics

1:10:24 Question to Abby: What do you like to have for breakfast the morning after you take Methotrexate

1:11:05 Question to Abby: Do you have many side effects the morning after you take Methotrexate and how long they last?

1:12:12 Question to Dr. Guzman: Are itchy feet and hot/cold sweats known as side effects of Methotrexate?

1:14:14 Questions related to reducing anticipatory nausea or how to deal with anxiety will be addressed by email and also a link to the past session related to behavioral depression will be shared.

1:14:43 Question to Abby and Dr. Guzman How common is dizziness with Methotrexate

1:15:30 Question to Dr. Guzman: Which administration is more effective: oral or subcutaneous?

1:17:25 Question to Abby and to Dr. Guzman: Have you heard about potentially doing injection in the stomach instead of arm?

1:19:24 Question to Dr. Guzman: When you increase the dosage of Methotrexate should you expect the side effects to be worse?

1:20:56 Question to Dr. Guzman: Can a child be on Methotrexate too long?

1:22:18 Question to Dr. Guzman: How Methotrexate support one another and how they work together?

1:23:50 Question to Abby: How do you feel with the addition of Humira? 

1:25:30 Question to Amy: What is your advice on talking with a rheumatologist or a nurse when you’re feeling unsure, or questioning whether Methotrexate works or it’s been too long

1:27:25 Closing remarks by Jennifer Wilson

1:29:00 Gratitude to all speakers

1:29:07 Information about a survey and next scheduled sessions

1:30:45 Information how to support and donate to Cassie+friends