This is a fascinating question and one for which there is accumulating but still minimal information.  There is some evidence that maternal use of antibiotics either before or during pregnancy or at the time of labor might result in changes in the microbiome of the child born to that mother. There have been no studies done specifically to investigate if maternal antibiotic use during pregnancy might affect the risk of the child developing JIA or uveitis.  We are currently doing a research study to investigate how inflammation during pregnancy might influence future disease in the offspring.  One facet of this study is to look at antibiotic use during pregnancy and the risk of the offspring having certain diseases later in life. We are also just about to begin a research project to study if the microbiome in the mouth influences the occurrence and course of JIA and if there is any connection with the oral microbiome and uveitis.