For many patients with CRMO, there is long term healing of the CRMO lesions.  The bone may be left with an area of what is called ‘sclerosis’, which is like a scar, but this doesn’t mean the bone is weak; it is like healing after a fracture.  It is less frequent that CRMO lesions have been so large, or in areas where longer term bone damage can cause difficulties.  

There is controversy at the present time about treatment of CRMO, with respect to whether treatment should be continued if there is a bone lesion when a patient is not having symptoms or progression.